Figure 9. Simulated I_KACh evoked by 100 nm ACh (left) and 3 μm Pilo (right) using a voltage-clamp protocol as in Fig. 5.

A, currents elicited by step depolarization to +60 mV, followed by voltage steps between −100 to 20 mV to measure ACh activation and Pilo deactivation. B, currents elicited by step hyperpolarization to −100 mV, followed by voltage steps between −100 to 20 mV to measure ACh deactivation and Pilo activation.