Table 2.
Comparison of data between three patient groups with grades I, II, and III hepatic echogenicity
| Variable | Grade I (Mean ± SD) (n= 17) | Grade II (Mean ± SD) (n= 14) | Grade I (Mean ± SD) (n= 10) | P value |
|---|---|---|---|---|
| BMI | 29.2 ± 1.7a | 33 ± 4b | 37.3 ± 6.6c | 0.0001* |
| W/H ratio | 0.9 ± 0.03a | 1 ± 0.04b | 1 ± 0.02b | 0.0001* |
| Cortisol (μg/dl) | 1.4 ± 0.5 | 1.4 ± 0.6 | 1.6 ± 0.6 | 0.7 |
| ACTH (pg/ml) | 4.9 ± 1.4 | 5 ± 1.3 | 4.9 ± 0.9 | 0.9 |
| Fasting blood glucose (mg/dl) | 89.8 ± 8 | 89.3 ± 10.6 | 95.2 ± 6.4 | 0.2 |
| Total cholesterol (mg/dl) | 167.8 ± 22.6a | 179.0 ± 20.6a | 194.9 ± 7.7b | 0.005* |
| Triglyceride (mg/dl) | 118.9 ± 38.0a | 135.1 ± 54.4a | 190.9 ± 30.5b | 0.001* |
| HDL-c (mg/dl) | 46.1 ± 9.6a | 40.1 ± 7.0b | 34.1 ± 5.3b | 0.002* |
| LDL-c (mg/dl) | 80.9 ± 24.4a | 91.3 ± 16.2b | 102.2 ± 16.1c | 0.03* |
| Insulin (μIU/ml) | 12.5 ± 5.4a | 15.8 ± 8.7ab | 19.6 ± 5.4b | 0.04* |
| C-peptide (ng/ml) | 1.4 ± 0.6a | 1.8 ± 0.9a | 2.6 ± 0.5b | 0.001* |
| HOMA-IR | 2.83 ± 1.33a | 3.44±1.70ab | 4.11 ± 1.16b | <0.05* |
| Total serum bilirubin (mg/dl) | 0.6 ± 0.3 | 0.6 ± 0.2 | 0.5 ± 0.2 | 0.5 |
| Direct serum bilirubin (mg/dl) | 0.5 ± 0.2 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.2 |
| AST (IU/l) | 32.6 ± 21.1 | 27.1 ± 6.2 | 37.3 ± 9.1 | 0.3 |
| ALT (IU/l) | 36.7 ± 8.4 | 33.9 ± 6.7 | 43.5 ± 9 | 0.8 |
| AP (IU/l) | 315.9 ± 55.6a | 331.6 ± 56.2a | 398.1 ± 57.1b | 0.002* |
| GGT (IU/l) | 32.5 ± 23.7 | 31.2 ± 8.1 | 38.6 ± 12.2 | 0.6 |
| Serum albumin (gm/dl) | 4.3 ± 0.2 | 4.4 ± 0.3 | 4.3 ± 0.2 | 0.3 |
| PC (%) | 87.1 ± 6.1 | 87.1 ± 8 | 91 ± 9.1 | 0.4 |
| Serum ferritin (μg/l) | 57.2 ± 1.9 | 65.1 ± 54.8 | 57.2 ± 19.6 | 0.8 |
| Liver histology | N (%) | N (%) | N (%) | |
| Normal (n=18) | 12 (66.7) | 6 (33.3) | 0 (0) | 0.01* |
| Simple steatosis(n=8) | 0 (0) | 5 (62.5) | 3 (37.5) | |
| NASH (n=7) | 0 (0) | 0 (0) | 7 (100) |
P value is significant if <0.05*
Different symbols indicate signifi cant difference. Figures in parenthesis are in percentage