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. Author manuscript; available in PMC: 2012 May 13.
Published in final edited form as: Cell. 2011 May 5;145(4):622–634. doi: 10.1016/j.cell.2011.03.042

Figure 1. GRO-seq provides a detailed view of the E2-regulated transcriptome in MCF-7 cells.

Figure 1

(A) Overview of the experimental set up for GRO-seq analysis using MCF-7 cells.

(B) Genome browser view for a specific locus showing GRO-seq (top) and Pol II ChIP-seq (bottom) data illustrating the features of transcription and the effects of estrogen treatment.

(C) De novo detection of transcripts using GRO-seq data (top) and an HMM (inset). Called transcripts (middle) match well to RefSeq annotations (bottom).

(D) Classification of transcripts based on the annotation filter (Fig. S1, E and F).

See also Figure S1.