Table 1.

Time Course and Radiochemical Yields During [¹⁸F]Fluoroanilinoquinazoline Syntheses.

Compound	Time Coursea (min)	% Radiochemical Yieldb
		a (ortho-F)	b (meta-F)	c (para-F)
[18F]Fluoronitrobenzenec	20	81± 2	44± 4	77± 5
[18F]Fluoroaniline	30	68± 2	35± 3	72± 6
[18F]1 (dimethoxy-)	90d	31± 5	17± 2	55± 2
[18F]2 (diethoxy-)	90d	19± 6	9± 3	36± 6

^a100% of activity at time of 0 min is attributed to [¹⁸F]Fluoride and represents the start of synthesis,

^bDecay-corrected relative to [¹⁸F]fluoride; n = 3–5,

^cPrecursor; 1,2- and 1,4-dinitrobenzene (a and c); 3-nitro-N,N,N-trimethylanilinium triflate (b),

^dFollowing preparative HPLC and sample concentration/formulation.