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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Behav Pharmacol. 2011 Feb;22(1):14–22. doi: 10.1097/FBP.0b013e3283423d92

Figure 1.

Figure 1

Discrimination testing in mice trained to discriminate 5 mg/kg dl-MPH (n = 7) or 2.5 mg/kg d-MPH (n = 6). A) The dose substitution curves of dl-MPH and d-MPH are parallel and the d-MPH curve is shifted to the left, consistent with the use of lower, albeit equimolar, doses compared to the dl-MPH curve. The ED50 values are 3.2 ± 0.3 and 1.5 ± 0.09 mg/kg for the dose response functions of dl-MPH and d-MPH, respectively. B) Response rates for both compounds declined slightly with increasing dose. However, responses were higher when mice were tested on their training dose for both compounds, indicated by arrows (▲) Values are means ± S.E.M.