Skip to main content
. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Behav Pharmacol. 2011 Feb;22(1):14–22. doi: 10.1097/FBP.0b013e3283423d92

Figure 3.

Figure 3

Training in the discrimination task with 1, 2 or 4 mg/kg dl-MPH (n = 24). Mice began training with 1 mg/kg, progressed to 2 mg/kg, and then finally were trained using 4 mg/kg. A) Total responses during the last 8 sessions on each dose on the appropriate lever (MPH or Saline) were similar across the entire experiment, regardless of dose. B) First Fixed Ratio (FFR) responses during the same sessions noted in panel A. Performance on the FFR for MPH or saline improved as the dose increased.. Thus, performance improved with increasing dose and mice reached criterion level responding (>80%) when the dose reached 4 mg/kg. In Panels A & B, the dotted lines indicate the mean responding for MPH and saline at each dose. Values are means ± S.E.M.