Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Predicted concentrations from the PK model that does not include the covariate CLCR (solid line). Predicted concentrations from a PK model that includes the covariate CLCR as a covariate on CL (dashed lines). Including the covariate CLCR in the model reduces the unexplained variability in the model predictions and hence improves the reliability of the model predictions
