Table 4.
AUC(0,3 h) values (pg ml−1 h) (± SD) of all study formulations, calculated for plasma (total concentrations), microdialysates from skeletal muscle (MD i.m.) and microdialysates from subcutaneous adipose tissue (MD s.c.) (free, non-protein bound concentrations)
| Treatment | Plasma AUC(0,3 h) | MD i.m. AUC(0,3 h) | MD s.c. AUC(0,3 h) |
|---|---|---|---|
| DCF100C1 (1%) | 4 755.4 ± 4 809.0 | 455.4 ± 468.6 | 648.4 ± 588.7 |
| DCF100C2 (1%) | 3 623.1 ± 2 278.0 | 939.2 ± 1030.0 | 1020.9 ± 1191.9 |
| DCF100C1 (2.5%) | 13 040.4 ± 10 869.8 | 572.3 ± 854.7 | 886.4 ± 816.0 |
| DCF100C2 (2.5%) | 11 245.0 ± 8 264.9 | 929.7 ± 1216.2 | 1732.5 ± 1678.5 |
| Voltaren® Emulgel® | 2 656.4 ± 1 981.4 | 832.2 ± 1205.9 | 1122.6 ± 1218.6 |
n = 12.