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A) ACTH and B) cortisol response to exercise (from time 0 for about 15 min) and exercise plus alprazolam (ALP) (50 µg given orally at time −90 min), naloxone (10 mg as an i.v. bolus at time 0) or ALP plus naloxone in 13 healthy normal male subjects. Each point represents the mean ± SE of the observations. Exercise (
); Exercise + ALP (
); Exercise + Naloxone (
); Exercise + Naloxone + ALP (
)
