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. Author manuscript; available in PMC: 2011 May 23.
Published in final edited form as: Lancet Neurol. 2009 Oct 29;8(12):1111–1119. doi: 10.1016/S1474-4422(09)70275-3

Table 4.

C-statistics for ROC curves and comparisons between models predicting MS.

Derivation Sample TT Sample NHS/NHS II Sample
c-statistic P value c-statistic P value c-statistic P value
wGRS without HLA 0.611 0.559 0.566
wGRS with HLA 0.697 <0.00012 0.636 <0.00012 0.637 0.01222
wGRS with HLA & covariates1 0.741 <0.00013 0.721 <0.00013 0.683 0.01893

Glossary: HLA – HLA DRB1*1501 allele.

1

For derivation and TT samples adjusted for covariate sex, for the NHS/NHS II sample adjusted for smoking (never, ever, current) and EBNA titer.

2

p-value compared to wGRS without HLA model

3

p-value compared to wGRS with HLA model