Table 4.
Derivation Sample | TT Sample | NHS/NHS II Sample | ||||
---|---|---|---|---|---|---|
c-statistic | P value | c-statistic | P value | c-statistic | P value | |
wGRS without HLA | 0.611 | 0.559 | 0.566 | |||
wGRS with HLA | 0.697 | <0.00012 | 0.636 | <0.00012 | 0.637 | 0.01222 |
wGRS with HLA & covariates1 | 0.741 | <0.00013 | 0.721 | <0.00013 | 0.683 | 0.01893 |
Glossary: HLA – HLA DRB1*1501 allele.
For derivation and TT samples adjusted for covariate sex, for the NHS/NHS II sample adjusted for smoking (never, ever, current) and EBNA titer.
p-value compared to wGRS without HLA model
p-value compared to wGRS with HLA model