TABLE 5.

Cox Proportional Hazards Analyses of AJCC Staging System

Variable	HR	95% CI	P	c-Statistic
T-Classification (M0, known size, n = 1054)
T2 (n = 996) vs. T1 (n = 58)	1.16	0.80–1.69	0.4	0.50
Stage grouping (n = 854)			<0.001	0.66
Stage I (n = 389): low- grade, any T, N0M0	Ref.	—
Stage II (n = 15): high- grade, T1, N0M0	1.68	0.82–3.42
Stage III (n = 281): high-grade, T2, N0M0	2.02	1.60–2.54
Stage IV (n = 167): N1 and/or M1	3.28	2.56–4.19

HR indicates hazard ratio; CI, Confidence interval; Ref, referent.