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. Author manuscript; available in PMC: 2012 Mar 18.
Published in final edited form as: Cell. 2011 Mar 18;144(6):940–954. doi: 10.1016/j.cell.2011.01.032

Figure 4. Signaling to core regulatory circuitry.

Figure 4

A) Model of an enhancer where transcription factors associated with Wnt, LIF and BMP4 signaling (STAT3, Tcf3 and Smad1) occupy sites near the core regulators.

B) Oct4 distal enhancer provides an example of a DNA element that is bound by the core regulators and signaling transcription factors and contains sequence motifs for each of these factors.

C) Frequency distribution showing how often signaling transcription factors (STAT3, Tcf3 and Smad1) are associated with Oct4/Sox2/Nanog-bound loci throughout genome. Binding was called at a high confidence (p<10−9) threshold within a 50bp window, so the actual number of signaling transcription factors bound to Oct4/Sox2/Nanog-occupied loci is somewhat higher.

ChIP-Seq data was obtained from GSE11431, GSE11724, GSE12680 and GSE22557.