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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Feb 24;252(3):211–220. doi: 10.1016/j.taap.2011.02.005

Figure 1. Dose response examination of HIF-1α in acetaminophen toxicity.

Figure 1

B6C3F1 male mice were treated with saline or acetaminophen at 15, 30, 100 or 200 mg/kg IP and sacrificed at 1 h. A. ALT values were comparable in all groups of mice. B. Western blot assays of HIF-1α induction in hepatic nuclear extracts demonstrated that HIF-1α was increased in all APAP-treated groups of mice (*p<0.05).