Table 2.

Slopes of pressure-flow curve, critical closing pressure and slopes of EMGgg-P_N from sickle cell disease subjects with and without OSAS using activated or hypotonic technique

	SCD OSAS		SCD Controls
	Activated	Hypotonic	Activated	Hypotonic
Slopes of EMGgg-PN (%/cm H2O)
Median	−3.3a	−3.8	−11.6	−1.9b
Range	−7.1 to 3.5	−4.0 to 3.3	−27.9 to −1.9	−11.3 to 1.5
95% CI	−9.6 to 4.5	−7.8 to 3.6	−17.8 to −8.0	−5.9 to −1.6
Pcrit (cm H2O)
Median	−17.4	−14.5	−25.0	−25.0c
Range	−25.0 to −4.2	−25.0 to −3.7	−25.0 to −6.3	−25.0 to −4.2
95% CI	−32.9 to 0.9	−33.9 to −5.0	−25.0 to −19.0	−21.6 to −14.8
Slopes of pressure-flow curve (mL/sec*cm H2O)
Median	10.6	25.7	4.5	10.8
Range	−5.1 to 60.3	1.0 to 72.7	−10.3 to 37.4	−21.2 to 32.4
95% CI	−27.1 to 65.3	−24.5 to 87.1	1.4 to 14.8	3.7 to 18.0
Holding pressure (cm H2O)
Median	3.1	3.3	1.2	1.5
Range	1.3 to 7.0	1.3 to 7.8	−1.8 to 5.1	−1.0 to 5.0
95% CI	−0.8 to 8.0	−1.0 to 8.8	0.4 to 2.4	0.9 to 2.5
Lowest pressure before arousal/apnea (cm H2O)
Median	−6.3d	−3.4e	−13.0	−13.0
Range	−6.8 to −4.4	−15.0 to −3.3	−20.3 to −3.1	−23.6 to −5.2
95% CI	−7.7 to −4.2	−15.6 to 3.4	−19.2 to −9.8	−10.4 to −15.1

^aSCD controls had more negative slopes of EMGgg-P_N than SCD OSAS when using the activated technique (P = 0.04).

^bFor SCD controls, the slope of EMGgg-P_N using the activated technique was more negative than that using the hypotonic technique (P < 0.001).

^cFor SCD controls, Pcrit was more negative using the activated technique than the hypotonic technique (P = 0.03).

^dSCD controls had a more negative lowest pressure before arousal/apnea than SCD OSAS using the activated technique (P = 0.03).

^eSCD controls had a more negative lowest pressure before arousal/apnea than SCD OSAS using the hypotonic technique (P = 0.02).