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Analysis of high ploidy MK by FISH
| Ploidy class | Control | STMN-WT | STMN-4A |
|---|---|---|---|
| 8N | 76.5 | 82.1 | 93.7 |
| 16N | 17.6 | 13.4 | 6.2 |
| 32N | 5.8 | 4.5 | 0 |
MKs with ≥ 8N DNA content were categorized in ploidy classes (8N, 16N, and 32N) based on the number of copies of each chromosome as illustrated in Figure 6. The numbers represent percentages of MKs in each culture condition: control, STMN-WT, and STMN-4A. More than 500 cells were analyzed in each condition in 2 independent experiments.
