Table 1. Summary of findings on BH3-only mice in seizure, ischemia, and trauma.

	Mechanism of activation	Response to insult	Knockout mouse phenotype and reference
Bid	Cleaved to tBid	Cleaved to tBid after seizure, ischemia, and TBI	No protection (seizures) (Engel et al, 2010a)
			Smaller infarcts (ischemia) (Plesnila et al, 2001; Yin et al, 2002)
			Reduced lesion volume (TBI) (Bermpohl et al, 2006)
Bim	Transcriptional induction (JNK, FoxO3a, CHOP)	Upregulated after seizure and ischemia	Mild protection in hippocampus but not cortex (seizures) (Murphy et al, 2010)
			Protection (ischemia) (Ness et al, 2006)
	Release from dynein light chain		Untested (TBI)
Puma	Transcriptional induction (p53, FoxO3a, CHOP, ER stress)	Upregulated after seizure and ischemia	Strong protection (seizure) (Engel et al, 2010b, 2010c)
			No protection (ischemia) (Kuroki et al, 2009)
			Untested (TBI)

BH3, Bcl-2 homology domain 3; ER, endoplasmic reticulum; JNK, c-Jun N-terminal kinase; TBI, traumatic brain injury.