TABLE 1.
Protein lysine methyltransferases in the yeast Saccharomyces cerevisiae have few mammalian orthologs
| Methyltransferase gene product | Methyltransferase superfamily | Substrate and methylated productsa | Methyltransferase ortholog in mammals? | Ref. |
|---|---|---|---|---|
| Rkm1 (YPL208W) | SET domain | Rpl23ab | No | 7 |
| Dimethyllysine 105 | ||||
| Dimethyllysine 109 | ||||
| Rkm2 (YDR198C) | SET domain | Rpl12ab | No | 19 |
| Trimethyllysine 3 | ||||
| Rkm3 (YBR030W) | SET domain | Rpl42ab | No | 9 |
| Monomethyllysine 40 | ||||
| Rkm4 (YDR257C) | SET domain | Rpl42ab | No | 9 |
| Monomethyllysine 55 | ||||
| Rkm5 (YLR137W) | Seven-β-strand | Rpl1ab | No | This study |
| Monomethyllysine 46 | ||||
| Efm1 (YHL039W) | SET domain | eEF1A | No | 17 |
| Monomethyllysine 30 or 390?b | ||||
| See1 | Seven-β-strand | eEF1A | Yes | 17 |
| (YIL064W) | Dimethyllysine 316?c | (human METTL10)e | ||
| Ctm1 (YHR109W) | SET domain | Cytochrome c Trimethyllysine 77d | No | 40 |
| Dot1 (YDR440W) | Seven-β-strand | Histone H3 | Yes | 25, 26 |
| Trimethyllysine 79 | (human DOT1L)f |
a Residue numbering based on mature protein (loss of initiator methionine) except for Rpl42ab and eEF1A.
b Sites of methylation suggested based on location of known monomethylated sites in yeast eEF1A (6, 17).
c Site of methylation suggested based on location of known dimethylated site in yeast eEF1A (6, 17).
d Methylation site in isoform 1; site at lysine 81 in isoform 2.
e 38% amino acid sequence identity over 182 residues.
f 28% amino acid sequence identity over 297 residues.