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Bruch's membrane thickness in 1-year-old BALB/c (WT) and albino abca4−/− mice. A, representative electron microscopic images of RPE/Bruch's membrane from WT (top) and KO (bottom) mice are shown. B, a histogram shows Bruch's membrane thickness (between the arrows) in WT and KO measured by electron microscopy. Scale bar = 4 μm. Values are shown as S.D. (n = 9; *, p < 0.00005).
