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. 2011 Apr 6;286(21):18982–18993. doi: 10.1074/jbc.M111.227793

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Stability of R₁₆ and K₁₆ polyplexes to anionic challenge by GAGs. R₁₆ and K₁₆ polyplexes were treated with increasing amounts of different GAGs (heparin, HS, CSA, and C6S) expressed as GAG:peptide w/w ratios. Stability was checked as a measure of the DNA released by agarose gel electrophoresis (the amount of DNA released was compared with uncomplexed plasmid DNA in lane 1 in A and B) and an ethidium bromide intercalation assay (the amount of DNA released was measured by the increase in the fluorescence by intercalation of EtBr; C and D). Fluorescence of free plasmid complexed to EtBr is taken as 100%. Values are plotted as percentage of maximum ± S.D.