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. Author manuscript; available in PMC: 2012 May 9.
Published in final edited form as: Neurosci Lett. 2011 Mar 23;495(1):55–59. doi: 10.1016/j.neulet.2011.03.034

Figure 4. Ischemia alters APP C-terminal fragments.

Figure 4

(a–b) Aβ-like staining, by 6E10 antibody, is not altered by immunohistochemistry 3-months post-ischemia. Quantification was performed using ImageJ and selecting an elliptical area of the CA1 (c) We did not find a difference in thioflavin staining. Arrows indicate areas of high thioflavin staining. (d–e) Western blot analysis of APP and APP-related proteins revealed a weight shift in the APP C-terminal fragment C83, but no changes in ADAM10, ADAM17 or BACE-1. We found a significant decrease in the γ-secretase components PS1 and Aph1 but not in PS2 (n=4 sham, 5 ischemia).