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. Author manuscript; available in PMC: 2012 May 9.
Published in final edited form as: Neurosci Lett. 2011 Mar 23;495(1):55–59. doi: 10.1016/j.neulet.2011.03.034

Figure 5. Ischemia induces long-term changes in APP phosphorylation and altered histone acetylation.

Figure 5

(a–b) Western blot analysis revealed a decrease in 180kDa APPT668 post-ischemia and an increase in 120kDa APPT668 in 3xTg-AD mice. Histone H3 acetylation was decreased in ischemia treated 3xTg-AD mice. We found a significant decrease in 60kd Fe65 and an increase in two higher molecular weight bands of Fe65, quantification included separately due to the scale(c). (d–e) APPT668 was increased in non-transgenic (Non-Tg) mice 3-months post ischemia. (f–g) 120kDa APPT668 was increased and 90kDa APPT668 was decreased in 3xTg-AD mice 24-hours post-ischemia.