Table 3.

Proposed criteria of AE of IPF by Collard and the IPF Clinical Research Network Invertigators [34].

Previous or concurrent diagnosis of IPF
Unexplained worsening or development of dyspnea within 30 days
HRCT with new bilateral ground-glass abnormality and/or consolidation superimposed on a background reticular or honeycomb pattern consistent with UIP pattern
No evidence of pulmonary infection by endotracheal aspirate or bronchoalveolar lavage
Exclusion of alternative causes, including the following: left heart failure, pulmonary embolism, identifiable cause of acute lung injury