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. Author manuscript; available in PMC: 2011 May 23.
Published in final edited form as: Nat Neurosci. 2010 Jun 6;13(7):877–882. doi: 10.1038/nn.2569

Figure 1.

Figure 1

Ghrelin and melanocortin action in the CNS control of plasma HDL-C. (a,b) Effect on cholesterol distribution of different lipoproteins after a 7-d icv infusion of ghrelin (2.5 nmol d−1) and SHU9119 (24 nmol d−1) (a) and after a 7-d icv infusion of SHU9119 (24 nmol d−1) and MTII (1 nmol d−1) in pair-fed rats (b). VLDL, very low density lipoproteins. (c) Apo B and A-I content in FPLC fractions from pooled plasma (n = 6–8) after a 7-d icv infusion of saline (Sal), ghrelin (GHR, 2.5 nmol d−1) and SHU9119 (SHU, 24 nmol d−1) in pair-fed Wistar rats. (d) Effect on HDL–3H-cholesterol ether plasma clearance of 4-d infusion of SHU9119 (10 nmol d−1) in rats. Icv infusion of SHU9119 significantly reduced HDL-C plasma clearance (P < 0.05, extra sum of squares F test, mean ± s.e.m., n = 9–10).