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. Author manuscript; available in PMC: 2011 May 23.
Published in final edited form as: Nat Neurosci. 2010 Jun 6;13(7):877–882. doi: 10.1038/nn.2569

Figure 2.

Figure 2

Altered plasma cholesterol in mutant mice deficient for ghrelin or melanocortin signaling. (a,b) Plasma cholesterol (a) and cholesterol content in FPLC fractions from pooled plasma (n = 6–8, b) of wild-type (WT), Ghrl−/− (Ghr KO), Ghsr−/− (Ghsr KO) and Ghrl−/−; Ghsr−/− (dKO) mice after an overnight fasting (*P < 0.05 versus wild type, one-way ANOVA, mean ± s.e.m., n = 6–8). (c,d) Plasma cholesterol in male (c) and female (d) wild-type, Mc3r−/− and Mc4r−/− overnight fasted mice maintained on diets with low (10% kJ from fat, LFD), moderate (45% kJ from fat, HFD) or very high (60% kJ from fat, VHFD) fat content (***P < 0.001 Mc4r−/− versus Mc3r−/− and wild type, **P < 0.01 Mc3r−/− versus wild type, two-way ANOVA, mean ± s.e.m., n = 3–10). (e,f) Fat mass (e) and plasma cholesterol (f) of Mc4r−/− mice (KO) compared with wild-type littermates and fat mass–matched (FMm) C57BL/6 mice (one-way ANOVA, mean ± s.e.m., n = 6–7).