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. Author manuscript; available in PMC: 2012 May 18.
Published in final edited form as: J Am Chem Soc. 2011 Apr 27;133(19):7602–7607. doi: 10.1021/ja2019299

Figure 2.

Figure 2

Potential of mean force (PMF) for folding of Ala10. (A) One-dimensional PMF for Ala10 in water as a function of the i, i + 4 hydrogen-bond ξ. The two inset proteins (green) represent example configurations for two values of ξ, respectively. (B) Two-dimensional PMF for Ala10 in the translocon as a function of the concerted-helix-formation coordinate ξ and translocation distance. The dotted line indicates the position of the translocon’s constrictive pore ring.