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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Pediatr Res. 2011 Apr;69(4):271–278. doi: 10.1203/PDR.0b013e31820efbcf

Figure 5. Caffeine protects against periventricular white matter injury.

Figure 5

(A) Representative coronal views of the lateral ventricles (arrow) for mice reared in hypoxia by dams drinking water (upper panel) or water containing caffeine (CAF; lower panel). Ventriculomegaly was not seen in mice reared in hypoxia by dams drinking water with caffeine. (B) Caffeine treatment during chronic sublethal hypoxia ameliorates reductions in cerebral myelination. Myelin basic protein (MBP) staining shows the typical myelination patterns of animals reared in normoxia (A) relative to those in chronic hypoxia treated with vehicle (Veh.; B) or with caffeine (Caf.; C). Scale bar: 1 mm. Reprinted from Back SA Ann Neurol 60:696–705; Copyright c 2006 American Neurological Association, with permission.