Table 2:

Biomarker validation requirements.

Establishment of how each biomarker is: related to time and type of injury correlated with base-line renal function modified by co-morbidities

Establish each biomarker’s role in renal causal injury pathway

Validate each biomarker against hard outcomes*

Validate biomarker panels against hard outcomes*

Develop point-of-care or rapid assays for each biomarker to allow timely intervention

^*need for renal replacement therapy and short- and long-term mortality.