Figure 4.

Comparison of the difference between the rates of decline in GFR (mL/min/1.73m² per year) as measured by isotopic-DTPA clearance and various indirect estimates of GFR in 19 patients with type 1 diabetes with a mean follow-up period of 10.1 years. Patients were selected for this analysis if they had a rate of GFR decline ≥3.3 mL/min/1.73m² per year. The initial reference-isotopic GFR was 105 and the final GFR was 52 mL/min/1.73m². Cr-GFR = 10⁴/serum creatinine; C-G = Cockcroft-Gault formula; MDRD-4 = Modification of Diet in Renal Disease four-variable formula; MDRD-6 = Modification of Diet in Renal Disease six-variable formula; Cys-1-GFR = (86.7/serum cystatin C concentration) - 4.2, Cys-2-GFR = 100/cystatin C. Adapted from Premaratne et al. with permission.⁶