Estimating Renal Function for Drug Dosing Decisions

. 2011 May;32(2):81–88.

Units for all formulae

Serum creatinine concentration (S Creat) in μmol/L; Weight (Wt) in kg; Height (Ht) in cm; Age in years

Estimated Creatinine Clearance (eCrCl)

Cockcroft and Gault formula¹:

eCrCl (mL / min) = [(140 - Age) \times Wt] / (0.813 \times S Creat) (\times 0.85 if female)

Estimated Glomerular Filtration Rate (eGFR)

MDRD formula with IDMS-aligned creatinine assays²:

eGFR-MDRD (mL / min / 1.73 m^{2}) = 175 \times {(S Creat \times 0.0113)}^{- 1.154} \times {age}^{- 0.203} (\times 0.742 if female)

CKD-EPI formula³:

\begin{array}{l} Females, S Creat > 62 μ mol / L \\ eGFR-CKD-EPI (mL / min / 1.73 m^{2}) = 144 \times {(S Creat \times 0.0113 / 0.7)}^{- 1.209} \times {0.993}^{age} \\ Females, S Creat \leq 62 μ mol / L \\ eGFR-CKD-EPI (mL / min / 1.73 m^{2}) = 144 \times {(S Creat \times 0.0113 / 0.7)}^{- 0.329} \times {0.993}^{age} \end{array}

\begin{array}{l} Males, S Creat > 80 μ mol / L \\ eGFR-CKD-EPI (mL / min / 1.73 m^{2}) = 141 \times {(S Creat \times 0.0113 / 0.9)}^{- 1.209} \times {0.993}^{age} \\ Males, S Creat \leq 80 μ mol / L \\ eGFR-CKD-EPI (mL / min / 1.73 m^{2}) = 141 \times {(S Creat \times 0.0113 / 0.9)}^{- 0.411} \times {0.993}^{age} \end{array}

Body Surface Area (BSA)

DuBois and DuBois formula⁴:

BSA (m^{2}) = 0.007184 \times {Ht}^{0.725} \times {Wt}^{0.425}

Mosteller formula⁵:

BSA (m^{2}) = \sqrt (Ht \times Wt / 3600)

Gehan and George formula⁶:

BSA (m^{2}) = 0.0235 \times {Ht}^{0.42246} \times {Wt}^{0.51456}

Body Surface Area Normalisation (and Removal)

BSA normalisation:

GFR (mL / min / 1.73 m^{2}) = GFR (mL / min) \times 1.73 / BSA

Removal of BSA normalisation:

GFR (mL / min) = GFR (mL / min / 1.73 m^{2}) \times BSA / 1.73

Direct removal of BSA normalisation (Jones⁷)

eGFR mL / min = eGFR (mL / min / 1.73 m^{2}) \times (Wt \times 6 + 600) / 1, 000

Ideal Body Weight

Approximated from Devine formula⁸:

Ideal Body Wt = 50 + 0.9 \times (Ht - 152) (- 4.5 if female)