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. 2011 May 23;6(5):e19847. doi: 10.1371/journal.pone.0019847

Figure 6. Changes in NADPH oxidase expression and activity.

Figure 6

(A). Changes in P47phox mRNA expression in frontal cerebral cortex in wild type mice exposed to IH (n = 8 per experimental group; *P<0.05). (B). Changes in NADPH oxidase activity in frontal cerebral cortex in wild type mice exposed to IH (n = 8 per experimental group; *P<0.05). (C) Kinetic NADPH oxidase activities in hippocampus measured as NADPH-dependent cytochrome c reduction. Shown are representative tracings from the four experimental groups. (D) Summary of NADPH oxidase activities in hippocampus. IH resulted in a substantial increase in NOX activities in wild type mice (*P = 0.002). Such IH-induced increases of NADPH oxidase activity were much attenuated in gp91phox _/Y mice, although the increase was still significant (†P = 0.024; n = 6 for each group).