Figure 3. Heat map of methylated gene in the Illumina Infinium methylation assay.

Heat map of 64 CpG locus were different methylated in 3 pairs of hepatocyte from HBHC(HHC) and adjacent liver(HA) with 2 normal liver(HN) as control(p<0.001). The hypermethylated and hypomethylated genes were indicated by red and green respectively. Unsupervised hierarchical cluster analysis represents a significent distinguishing HHCs from HAs and HNs. The Euclidean distance between two groups of samples is calculated by the average linkage measure between members of the two groups concerned.