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. 2011 May 23;6(5):e20041. doi: 10.1371/journal.pone.0020041

Figure 5. DGE lists reveal heterogeneity in human Proneural GBM.

Figure 5

(A) GSEA of mouse tumors with DGE lists of Ptenf/f vs. Ptenf/f; p53f/f mouse tumors. Sample wise: Ptenf/f; p53f/f tumors were labeled as blue and Ptenf/f tumors as green. Red to blue color scale shows the range from the highest to lowest enrichment score. (B) GSEA ranking of TCGA Proneural patients with DGE lists of Ptenf/f vs. Ptenf/f; p53f/f mouse tumors. Horizontal red line on top of panel labels 1/3 of Proneural patients that most resemble Ptenf/f; p53f/f tumors, while blue line labels 1/3 of patients that most resemble Ptenf/f tumors. Similar patients from four datasets are pooled together to compare survival as in (C). Sample wise: Proliferative is labeled as blue, Mesenchymal as red and the rest of Proneural as green (See discussion). (C) Kaplan-Meier survival curve comparison of patients that resemble Ptenf/f; p53f/f mouse tumor vs. those that resemble Ptenf/f mouse tumor.