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. Author manuscript; available in PMC: 2012 May 30.
Published in final edited form as: Chem Biol Interact. 2011 Jan 27;191(1-3):234–238. doi: 10.1016/j.cbi.2011.01.019

Table 1.

Kinetic Parameters for the Reactions Catalyzed by AKR1D1 and AKR1C4.

Steroid AKR1D1
(double bond reduction)		 AKR1C4
(20-keto reduction)
Vmax
(nmol min−1)		 Km (μM) Vmax/Km
(nmol min−1μM−1)		 Activity
(nmol min−1mg−1)
cortisol 58 ± 4 13 ± 2 4.4 13.2 ± 0.6
BUD 9 ± 1 22 ± 6 0.4 0.8 ± 0.2
FLU 30 ± 3 31 ± 7 1.0 4.9 ± 0.5