Skip to main content
. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Exp Neurol. 2011 Apr 2;229(2):471–483. doi: 10.1016/j.expneurol.2011.03.018

Figure 12. The effects of KCNQ2/3 channel activity on endocytosis and exocytosis in hippocampal neurons.

Figure 12

Fluorescent styryl-dye FM4-64 was used to monitor endocytosis and exocytosis in primary cultured hippocampal neurons underwent 7 or 14 day treatment with the KCNQ channel blocker XE991 or linopirdine. The blocker was added into the media at 1 DIV. A. After treated with XE991 or linopirdine for 7 days, there was no significant difference in the intensities of FM4-64 in each group. B. After 14-day treatment, the intensity of FM4-64 for endocytosis was much less in XE991- or linopirdine-treated groups compared to control groups. On the other hand, the FM4-64 intensity for exocytosis was higher in inhibitor-treated groups. Mean ± S.E. M. N ≥ 3 independent experiments. * P < 0.05 vs. vehicle controls.