Skip to main content
. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Exp Neurol. 2011 Apr 2;229(2):471–483. doi: 10.1016/j.expneurol.2011.03.018

Figure 5. Blocking KCNQ2/3 channels reduced synaptophysin expression in hippocampal neurons.

Figure 5

The effects of KCNQ channel inhibitors on synaptophysin expression in hippocampal neurons. A. Hippocampal cultures were exposed for either 7 or 14 days with KCNQ channel inhibitors, XE991 (10 μM) or linopirdine (30 μM). The inhibitor was added into the culture media at 1 DIV. Immunostaining showed that both inhibitors decreased synaptophysin expression. B and C. Quantification of synaptophysin fluorescent intensities in control cells and cells treated with XE991 or linopirdine for 7 (B) and 14 (C) days. Mean ± S.E. M. N ≥ 3 independent experiments. * P < 0.05 vs. vehicle controls.