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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Exp Neurol. 2011 Apr 2;229(2):471–483. doi: 10.1016/j.expneurol.2011.03.018

Figure 6. Blocking KCNQ2/3 selectively increased ERK1/2 phsophorylation.

Figure 6

Western blot analysis was performed to inspect the total and phosphorylated protein levels of several intracellular signaling molecules in ES cell-derived neural progenitor cells. Both XE991 and linopirdine (5 day exposure) enhanced the levels of phsophorylated ERK1/2 (pERK). The bar graph shows that, due to the increased pERK1/2 and/or decreased total ERK (tERK), the ratio of pERK versus tERK was significantly increased. Meanwhile, Src phosphorylation was not significantly changed. N = 5; *. P < 0.05 vs. controls.