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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Exp Neurol. 2011 Apr 2;229(2):471–483. doi: 10.1016/j.expneurol.2011.03.018

Figure 7. KCNQ2/3 channel opener enhanced synaptophysin expression.

Figure 7

Mouse stem cell-derived neurons were treated with the KCNQ2/3 channel opener NEM at different concentrations for 5 days. A. Immunostaining showed NEM (2 μM) dramatically increased synaptophysin expression, the effect was completely prevented by co-applied KCNQ channel blocker, XE991 (10 μM). B. The bar graph summarized quantified the synaptophysin fluorescent intensity in experiments in A. NEM showed a dose-response effect on synaptophysin expression and its blockade by XE991. Mean ± S.E. M. N ≥ 3 independent experiments. * P < 0.05 vs. vehicle controls. # P < 0.05 vs. NEM application.