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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Biomaterials. 2011 Apr 13;32(22):5065–5076. doi: 10.1016/j.biomaterials.2011.03.053

Figure 4. SATB2 promotes bone healing in the skull assay.

Figure 4

(A) Surgical procedure. (a) A non-healing full thickness defect of 4 mm diameter in the either side of the cranial bone was made; (b) the cranial defect was filled with a silk scaffold seeded with gene-modified iPSCs; (c) Representative picture of the healing wound 5 weeks after implantation. (B) Representative pictures showed large defined radiopacities at the defect sites in scaffold alone group and little calluses observed restrict to the defect margin in untransduced iPSCs derived from EB without OS, while an obviously superior extent in untransduced iPSCs derived from EB with OS group, and Vector-transduced iPSCs with OS group. Moreover, SATB2 transduction into iPSCs further closed the defects. (C) Microcomputer tomography (microCT) images of cranial bony defects taken 5 weeks after implantation. Scale bar =1 mm.