Table 2.
Chr | cM | Parametric (full pedigrees) | Nonparametric | Affected only | |||||
---|---|---|---|---|---|---|---|---|---|
LOD | HLOD | α | NPL | P | LOD | HLOD | α | ||
Regions identified from genome-wide screen on Family 1 | |||||||||
2q (Region 1) | 193–199 | 0.48 | 0.48 | 0.95 | 2.36 | 0.004 | 1.12 | 2.09 | 0.54 |
2q (Region 2) | 224–231 | 0.79 | 0.96 | 0.60 | 1.75 | 0.018 | 0.82 | 1.73 | 0.54 |
2p | 2–34 | −1.06 | 0.04 | 0.15 | 1.36 | 0.04 | −1.23 | 0.60 | 0.38 |
8 | 39–89 | −1.56 | 0.00 | 0.00 | 0.86 | 0.14 | −1.73 | 0.41 | 0.17 |
Chr | cM | Parametric (full pedigrees) | Nonparametric | Affected only | |||
---|---|---|---|---|---|---|---|
LOD | HLOD | NPL | P | LOD | HLOD | ||
Previously published CRC susceptibility loci | |||||||
3 | 126–190 | −1.22 | 0.18 | 0.57 | 0.27 | −5.47 | 0.09 |
7 | 111–129 | −2.76 | 0.00 | 0.83 | 0.15 | −3.32 | 0.05 |
9 | 66–121 | −1.86 | 0.00 | 0.37 | 0.42 | −5.16 | 0.00 |
α proportion of linked families