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Pancreas epithelium-specific KrasG12D expression. Cre recombinase is expressed under the promoter of PDX1 or Ptf1a gene, which is pancreas epithelium-specific. Without cre recombinase expression, a stop sequence between the loxP sites prevents mutant KrasG12D expression. In cells where only cre recombinase is expressed, the stop sequence is cut out, which turns on the pancreas epithelium-specific KrasG12D expression at a physiological level under the native Kras promoter.
