Table 2.

Relative Risk for Barrett's Esophagus According to Smoking Status

	Smoking Status
	Never	Former (1-24 cigarettes per day)	Former (25+ cigarettes per day	Current (1-24 cigarettes per day)	Current (25+ cigarettes per day)
Specialized Intestinal Metaplasia Cases/women, n/n	152 / 9177	159 / 7562	37 / 1524	20 / 1573	4 / 335
Age-adjusted OR (95% CI)	1.00 (reference)	1.23 (0.98-1.54)	1.43 (0.99-2.06)	0.80 (0.50-1.28)	0.78 (0.29-2.11)
Multivariate OR (95% CI)	1.00 (reference)	1.25 (0.99-1.59)	1.52 (1.04-2.22)	0.89 (0.54-1.45)	0.92 (0.34-2.54)
Specialized Intestinal Metaplasia ≥ 1cm Cases/women, n/n	58 / 9083	62 / 7624	16 / 1540	10 / 1583	2 / 337
Age-adjusted OR (95% CI)	1.00 (reference)	1.25 (0.88-1.80)	1.61 (0.93-2.81)	1.01 (0.51-1.98)	0.97 (0.23-3.97)
Multivariate OR (95% CI)	1.00 (reference)	1.24 (0.85-1.83)	1.70 (0.95-3.05)	1.04 (0.50-2.13)	1.12 (0.27-4.70)
Columnar Histology with or without Specialized Intestinal Metaplasia Cases/women, n/n	189 / 9214	194 / 7756	47 / 1571	27 / 1600	5 / 340
Age-adjusted OR (95% CI)	1.00 (reference)	1.21 (0.99-1.48)	1.46 (1.06-2.02)	0.86 (0.57-1.29)	0.78 (0.31-1.88)
Multivariate OR (95% CI)	1.00 (reference)	1.21 (0.98-1.50)	1.51 (1.08-2.11)	0.94 (0.61-1.43)	0.87 (0.35-2.16)

Multivariate ORs are adjusted for year of endoscopy; age (5-year categories); body mass index (weight in kilograms divided by the square of the height in meters; <20, 20-24.9, 25-29.9, ≥30); physical activity (<1.7, 1.7 to 4.5, 4.6 to 10.5, 10.6 to 22.1, and >22.1 metabolic equivalent task score per week); daily caloric intake/day (quartiles); alcohol consumption (0, 0.1 to 4.9, 5.0 to 15.0, and >15g/day); and postmenopausal hormone use (premenopausal, never, past, current).

OR = odds ratio; CI = confidence interval