Table 3.

Relative Risk for Barrett's Esophagus According to Pack-years of Cigarette Use

	Pack Years of Cigarette Smoking
Smoking Status*	0	1-10	11-25	26-50	>50	P Value for Trend
Ever Smokers
Cases/Total	152 / 9177	70 / 3897	63 / 3029	56 / 3085	29 / 1230
Multivariate OR (95% CI)	1.00 (reference)	1.09 (0.81-1.48)	1.26 (0.92-1.73)	1.23 (0.89-1.69)	1.45 (0.95-2.22)	0.05
Former Smokers
Cases/Total	152 / 9177	69 / 3775	58 / 2725	48 / 2177	18 / 618
Multivariate OR (95% CI)	1.00 (reference)	1.12 (0.83-1.52)	1.25 (0.91-1.73)	1.44 (1.02-2.02)	1.70 (1.00-2.89)	0.008

Multivariate ORs are adjusted for year of endoscopy; age (5-year categories); body mass index (weight in kilograms divided by the square of the height in meters; <20, 20-24.9, 25-29.9, ≥30); physical activity (<1.7, 1.7 to 4.5, 4.6 to 10.5, 10.6 to 22.1, and >22.1 metabolic equivalent task score per week); daily caloric intake/day (quartiles); alcohol consumption (0, 0.1 to 4.9, 5.0 to 15.0, and >15g/day); and postmenopausal hormone use (premenopausal, never, past, current).

^*Due to a limited number of current smokers, stable modeling stratified by pack-year categories could not be accomplished for this group of smokers. However, a p-value of 0.99 was obtained modeling pack-years as a continuous variable for current smokers.

OR = odds ratio; CI = confidence interval