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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Eur J Immunol. 2011 Mar 1;41(4):926–935. doi: 10.1002/eji.201041040

Figure 3. Effects of PA28 and immunosubunits on CD4:CD8 T cell ratios in lymphoid tissues of uninfected mice.

Figure 3

(A) CD8 T cells were detected in the spleens of B6 wt, PA28-/-, β5i/LMP7+β2i/MECL-1-/- and PA28+β5i/LMP7+β2i/MECL-1-/- mice by staining with anti-CD8α mAb and FACS analysis. Frequencies of CD8 T cells as percentage of total lymphocytes are shown (means plus SEM, n=3). (B) CD4:CD8 T cell ratios in spleen and thymus of B6 wt, PA28-/-, β5i/LMP7+β2i/MECL-1-/- and PA28+β5i/LMP7+β2i/MECL-1-/- mice. Data are representative for two independent experiments (means plus SEM; n=3).