Table 1.
Change in Cognitive Function Before and After Dementia Onset in Alzheimer's Disease*
WB: from rerun.requst12.using_estimate.txt
| Cognitive Outcome | Model Term | Estimate | St.Error | P |
|---|---|---|---|---|
| Global Cognition | Time preceding prodrome | -0.013 | 0.001 | <.001 |
| Time during prodrome | -0.209 | 0.005 | <.001 | |
| Time after dementia onset | -0.282 | 0.014 | <.001 | |
| Episodic Memory | Time preceding prodrome | 0.0003 | 0.002 | .862 |
| Time during prodrome | -0.251 | 0.007 | <.001 | |
| Time after dementia onset | -0.283 | 0.016 | <.001 | |
| Perceptual Speed | Time preceding prodrome | -0.044 | 0.002 | <.001 |
| Time during prodrome | -0.227 | 0.007 | <.001 | |
| Time after dementia onset | -0.265 | 0.014 | <.001 | |
| Working Memory | Time preceding prodrome | -0.020 | 0.001 | <.001 |
| Time during prodrome | -0.120 | 0.005 | <.001 | |
| Time after dementia onset | -0.217 | 0.014 | <.001 | |
| Semantic Memory | Time preceding prodrome | -0.013 | 0.001 | <.001 |
| Time during prodrome | -0.157 | 0.006 | <.001 | |
| Time after dementia onset | -0.281 | 0.018 | <.001 | |
| Visuospatial ability | Time preceding prodrome | -0.013 | 0.001 | <.001 |
| Time during prodrome | -0.181 | 0.007 | <.001 | |
| Time after dementia onset | -0.283 | 0.018 | <.001 |
*
From separate mixed-effects models adjusted for age, sex, education. Each estimate is the mean annual rate of cognitive change predicted by the model.