Table 1.
Effect of Centella asiatica (CA; 150 and 300 mg/kg, p.o.) on memory performance in Morris water maze in D-galactose-treated mice.
| Treatment (mg/Kg) | Day 20 (IAL) | Day 21 (1st RL) | Day 42 (2nd RL) |
|---|---|---|---|
| Naïve | 48.1 ± 2.9 | 17.3 ± 3.2 | 12.3 ± 1.4 |
| D-gal (100) | 49.8 ± 3.0 | 58.0 ± 2.2a | 55.1 ± 1.7a |
| CA (300) | 48.6 ± 2.6 | 12.5 ± 2.5 | 9.5 ± 2.4 |
| CA (150) + D-gal (100) | 46.5 ± 2.56 | 43.0 ± 2.7b | 40.6 ± 2.6b |
| CA (300) + D-gal (100) | 46.3 ± 2.7 | 28.5 ± 2.5b,c | 25.6 ± 2.4b,c |
The initial acquisition latencies (IAL) on day 20 and retention latencies on days 21 (1st RL) and 42 (2nd RL) following D-gal concurrent treatment were observed. Values are mean ± S.E.M. aP < .05 as compared to naive group; bP < .05 as compared to D-gal-treated group; cP < .05 as compared to CA (150) + D-gal group (repeated measures two-way ANOVA followed by Tukey's test for multiple comparisons).