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Effect of vinblastine on the expression of CYP3A4 protein in HepG2 cells. Cells were treated with vinblastine for 48 hours as indicated and CYP3A4 protein expression was determined by Western blot analysis. Human CYP3A4 plus reductase BD Supersomes were used as a positive control (far right lane). The range used corresponds to vinblastine concentrations of 0.165 μM (150 ng/mL) to 5.28 μM (4800 ng/mL)
