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. Author manuscript; available in PMC: 2011 May 24.
Published in final edited form as: Ann Pharmacother. 2010 Oct 19;44(11):1709–1717. doi: 10.1345/aph.1P354

Figure 3.

Figure 3

Effect of vinblastine and valspodar (PSC 833) on the transcriptional activity of NR1I2 in HepG2 cells co-transfected with the pSG5-hPXR and pSG5-mPXR expression plasmids and CYP3A4-PXRE2-LUC reporter plasmid. Rifampin (10 μM) and pregnenolone-16α-carbonitrile (PCN; 50 μM) were used as positive controls. Experiments were performed twice in triplicate, except for vinblastine 150 ng/mL for pSG5-hPXR (n = 1). Error bars are standard error of the mean. The range used corresponds to vinblastine concentrations of 0.165 μM (150 ng/mL) to 5.28 μM (4800 ng/mL).