Table 1.
Patient Demographics and Genotypes
| Pts. |
ECOG PS |
% ↑ Midazolam Cl |
CYP3A4*1B | CYP3A4*17 | CYP3A4*18A | CYP3A5*3C | CYP3A5*6 | ABCB13435C>T | |
|---|---|---|---|---|---|---|---|---|---|
| Sex | Age, y | ||||||||
| Male | 55 | 1 | 51.7 | *1A/*1A | *1A/*1A | *1A/*1A | *3C/*3C | *1A/*1A | CT |
| Male | 60 | 0 | 35.9 | *1A/*1B | *1A/*1A | *1A/*1A | *1A/*3C | *1A/*1A | TT |
| Male | 58 | 1 | 216.7 | *1A/*1A | *1A/*1A | *1A/*1A | *3C/*3C | *1A/*1A | CT |
| Male | 40 | 1 | 2.5 | *1A/*1A | *1A/*1A | *1A/*1A | *3C/*3C | *1A/*1A | CT |
| Male | 50 | 1 | 46.9 | *1A/*1A | *1A/*1A | *1A/*1A | *3C/*3C | *1A/*1A | CC |
| Female | 66 | 1 | 6.9 | *1A/*1A | *1A/*1A | *1A/*1A | *3C/*3C | *1A/*1A | CT |
Cl = clearance; ECOG PS = Eastern Cooperative Oncology Group Performance Status.