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. Author manuscript; available in PMC: 2012 May 26.
Published in final edited form as: J Med Chem. 2011 May 2;54(10):3581–3594. doi: 10.1021/jm200288r

Scheme 2. Synthesis of Amine-linked Analoguesa.

Scheme 2

aReagents and conditions: (a) hydrazine, EtOH, reflux, 3 h; (b) propionylchloride, CH2Cl2, TEA, 0 °C to RT, 4 h; (c) LAH, THF, reflux, 4 h (d) aldehyde, Na(OAc)3BH, DCE, RT, 24 h (Method C); (e) 9H-fluorene-2-carbaldehyde, MeOH, RT, 12h; (f) NaBH4, 30 min; (g) HCHO, Na(OAc)3BH, DCE, 12 h.