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. Author manuscript; available in PMC: 2012 May 26.
Published in final edited form as: J Med Chem. 2011 May 2;54(10):3581–3594. doi: 10.1021/jm200288r

Table 1.

Human D2R-Family Receptor Subtype Binding Data on N-(3-Fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl) piperazine-1-yl)-butyl)-aryl carboxamidesa

graphic file with name nihms290427u1.jpg
compd R Ar clogPb D2R D3R D4R D2/D3 D4/D3
Ki±S.E.M, nM
8a 2-OCH3 graphic file with name nihms290427t1.jpg 3.9 390±42 20.5±4.3 ND 19 -
8b 2,3-diCl graphic file with name nihms290427t2.jpg 5.5 378±42 6.20±1.5 3090±650 61 498
8c 2-OCH3 graphic file with name nihms290427t3.jpg 3.7 329±36 28.6±6.0 ND 11 -
8d 2,3-diCl graphic file with name nihms290427t4.jpg 5.3 14600±5070 (9160±3730) 6.10±0.8 (5.40±0.6) 5340±2290 2400 (1700)c 875
8e 2-OCH3 graphic file with name nihms290427t5.jpg 4.0 274±13 13.9±1.1 ND 20 -
8f 2,3-diCl graphic file with name nihms290427t6.jpg 4.9 279±63 8.00±1.4 ND 35 -
8g 2-OCH3 graphic file with name nihms290427t7.jpg 3.7 421±33 9.50±1.9 1490±39.6 44 157
8h 2,3-diCl graphic file with name nihms290427t8.jpg 5.4 526±51 4.00±0.9 3360±484 131 841
8i 2-OCH3 graphic file with name nihms290427t9.jpg 5.1 2890±1040 10.1±1.9 3180±922 286 315
8j 2,3-diCl graphic file with name nihms290427t10.jpg 6.1 4260±1990 2.60±0.7 ND 1640 -
8k 2-OCH3 graphic file with name nihms290427t11.jpg 3.7 241±38 3.80±0.8 ND 63 -
8l 2,3-diCl graphic file with name nihms290427t12.jpg 5.4 472±76 2.90±0.4 ND 163 -
8m 2-OCH3 graphic file with name nihms290427t13.jpg 3.3 302±32 4.60±0.4 ND 66 -
8n 2,3-diCl graphic file with name nihms290427t14.jpg 4.8 230±16 1.50±0.3 ND 153 -
8o 2,3-diCl graphic file with name nihms290427t15.jpg 5.3 195±25 6.10±0.9 ND 32 -
1d - - 5.3 93.3±12.0 0.7±0.1 375±18 133 540
(±)2e - - 4.2 502±51.5 1.39±0.19 4900±1034 358 5300
a

Binding inhibition values determined using HEK 293 cells transfected with hD2LR or hD3R and125I-IABN radioligand as described.5,6

b

Partition coefficients (clogP) were calculated using ChemDraw Ultra, Version 11.0, CambridgeSoft 2007;

c

D2/D3 ratio using Ki values from chimera study in Table 4;

d

data previously reported in ref. 5;

e

data previously reported in ref. 11; ND = Not determined.